Wee1-like protein kinase (IPR017164)

Short name: Wee1-like_protein_kinase

Overlapping homologous superfamilies

Family relationships



This group represents a Wee1-like protein kinase (EC:, which is a key regulator for G(2)-to-M progression. This enzyme phosphorylates Tyr15 on Cdc2 (cell division control protein 2) when Cdc2 is complexed to cyclin B1, which results in blocking the progression of cells into M phase [PMID: 18385244]. As such, it negatively regulates the entry of a cell into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed Cdc2 before the onset of mitosis [PMID: 9016762, PMID: 17480229]. The activity of this enzyme increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated; it is then ubiquitinated and degraded at the onset of G2/M phase.

GO terms

Biological Process

GO:0000278 mitotic cell cycle

Molecular Function

GO:0000287 magnesium ion binding
GO:0004715 non-membrane spanning protein tyrosine kinase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.