Type 2 lantibiotic biosynthesis protein LanM (IPR017146)

Short name: Lanti_2_LanM

Overlapping homologous superfamilies


Family relationships



Lantibiotics are peptide antimicrobials characterized by the unique amino acids lanthionine and methyllanthionine, which are introduced by dehydration of Ser/Thr residues and linkage of the resulting dehydrated amino acids with Cys residues. Members of this family are known generally as LanM, a multifunctional enzyme of lantibiotic biosynthesis [PMID: 19561184]. This catalysis by LanM distinguishes the type 2 lantibiotics, such as lacticin 481, mersacidin, cinnamycin, and lichenicidin, from LanBC-produced type 1 lantibiotics such as nisin and subtilin.

The N-terminal domain of LanM enzymes contains regions associated with Ser and Thr dehydration [PMID: 25971839]. The C-terminal region is a LanC-type domain (IPR007822) that catalyses the formation of the lanthionine bridge [PMID: 23071302].

In most lantibiotic-producing bacteria LanM modifies only a single lantibiotic precursor peptide. However, marine Prochlorococcus and Synechococcus contain multiple lantipeptide precursor lanA-like genes but only a single lanM-like gene [PMID: 20479271].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.