Family

Cholesteryl ester transfer (IPR017130)

Short name: Cholesteryl_ester_transfer

Overlapping homologous superfamilies

None.

Family relationships

Description

This group represents cholesteryl ester transfer protein, also known as lipid transfer protein 1. This protein shuttles various lipids between lipoproteins, resulting in the net transfer of cholesteryl esters from atheroprotective, high-density lipoproteins (HDL) to atherogenic, lower-density species. Thus, inhibtion of this enzyme raises the concentration of protective HDL and could conceivably be used as a treatment for cardiovascular disease. The protein forms a long tunnel which can accomodate four lipid molecules [PMID: 17237796].

GO terms

Biological Process

GO:0043691 reverse cholesterol transport

Molecular Function

GO:0017127 cholesterol transporter activity

Cellular Component

GO:0034364 high-density lipoprotein particle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PIRSF