Catechol O-methyltransferase, eukaryotic (IPR017128)

Short name: Catechol_O-MeTrfase_euk

Overlapping homologous superfamilies

Family relationships


This entry represents a family of catechol O-methyltransferases found in eukaryotes. Catechol O-methyl transferase (COMT), along with several other enzymes, degrades catecholamines such as dopamine, epinephrine and norepinephrine. It introduces a methyl group, donated by S-adenosyl methionine (SAM) to the catecholamine. It is found in the postsynaptic neurons [PMID: 9605753]. COMT inactivates catecholamines as well as catechol drugs such as L-DOPA. It is possible that the COMT gene is involved in neuropsychiatric conditions in which there are abnormalities in catecholamine neurotransmission, including mood disorders, schizophrenia, obsessive compulsive disorder, alcohol and substance abuse and attention deficit hyperactivity disorder [PMID: 8807664]. An association between the COMT Val158Met polymorphism and aggressive schizophrenia has been established.

GO terms

Biological Process

GO:0006584 catecholamine metabolic process
GO:0042135 neurotransmitter catabolic process

Molecular Function

GO:0016206 catechol O-methyltransferase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.