Family

Peptidase S1A, matriptase-2 (IPR017118)

Short name: Pept_S1A_matriptase-2

Overlapping homologous superfamilies

Family relationships

Description

This entry contains serine peptidases belonging to MEROPS petidase family S1A (clan PA(S)), members are annotated as matriptase-2. Matriptase-2 is a type II transmembrane serine peptidase that plays a crucial role in body iron homeostasis by down-regulating hepcidin expression, which results in increased iron levels [PMID: 18451267, PMID: 20684597].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF