Family

Adaptor protein complex AP-3, delta subunit (IPR017105)

Short name: AP3_complex_dsu

Family relationships

None.

Description

The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptor protein complex 3 (AP-3) appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.

AP-3 is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). The subunits of non-clathrin- and clathrin-associated adaptor protein complex 3 play a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or in endosomes.

This group represents an adaptor protein complex AP-3, delta subunit.

GO terms

Biological Process

GO:0015031 protein transport

Molecular Function

GO:0008565 protein transporter activity

Cellular Component

GO:0005794 Golgi apparatus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF