Adaptor protein complex AP-2, alpha subunit (IPR017104)

Short name: AP2_complex_asu

Overlapping homologous superfamilies

Family relationships



Adaptor protein complex AP-2 has a role in clathrin-mediated endocytosis and intracellular transport [PMID: 26749213]. AP-2 links clathrin to membrane lipids and transmembrane cargoes at the vesicle budding site [PMID: 24322426]. It consists of two large subunits termed adaptins (alpha and beta subunits), a medium-sized one (mu), and a small one (sigma). It is thought to act in cargo selection by interaction with selection motifs encoded in the cytoplasmic tails of cargo molecules. The N-terminal domains of the adaptins, together with the mu and sigma subunits, constitute the 'head' of the adaptor, which interacts with plasma membrane lipids and cargoes. AP-2 plays a role in the recycling of synaptic vesicle membranes from the presynaptic surface [PMID: 25654254].

This family represents the alpha subunit of adaptor protein complex AP-2.

GO terms

Biological Process

GO:0072583 clathrin-dependent endocytosis
GO:0015031 protein transport

Molecular Function

GO:0035615 clathrin adaptor activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.