Adaptor protein complex AP-2, alpha subunit (IPR017104)

Short name: AP2_complex_asu

Family relationships



The adaptor protein complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. The adaptor protein complex 2 (AP-2) appears to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface.

AP-2 is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). It is a component of a complex composed at least of ACTB, AP2M1, AP2A1, AP2A2, MEGF10 and VIM, which interacts with RAB11FIP2. The subunits of clathrin-associated adaptor protein complex 2 play a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or in endosomes.

This group represents an adaptor protein complex AP-2, alpha subunit.

GO terms

Biological Process

GO:0015031 protein transport

Molecular Function

GO:0008565 protein transporter activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.