mRNA capping enzyme, bifunctional (IPR017074)

Short name: mRNA_cap_enz_bifunc

Overlapping homologous superfamilies


Family relationships



This entry represents bifunctional mRNA-capping enzymes that exhibit RNA 5'-triphosphatase activity (EC: in the N-terminal region and mRNA guanylyltransferase activity (EC: in the C-terminal region. These enzymes catalyse the first two steps of cap formation via the following steps:

  • Removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end.
  • Followed by the transfer of the gmp moiety of GTP to the 5'-diphosphate terminus.

GO terms

Biological Process

GO:0006370 7-methylguanosine mRNA capping

Molecular Function

GO:0004484 mRNA guanylyltransferase activity
GO:0004651 polynucleotide 5'-phosphatase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.