Family

Transcription elongation factor Spt6 (IPR017072)

Short name: TF_Spt6

Family relationships

None.

Description

This family consists of several eukaryotic nuclear transcription elongation proteins characterised by an extremely acidic N-terminal region. In yeast, increased or decreased dosage of Spt6 protein can change gene expression [PMID: 8786132]. In addition, all members contain a YqgFc domain. This domain is found primarily in low-GC Gram-positive bacteria Holliday junction resolvases. However, in Spt6 orthologues, the catalytic residues are substituted, indicating that they lack resolvase activity. Some members contain a copy of the S1 domain (IPR003029) that occurs in a wide range of RNA associated proteins. It is structurally similar to cold shock protein, which binds nucleic acids. The S1 domain has an OB-fold structure. Adjacent to this domain one to two copies of the SH2 domain are present (IPR000980) which are regulatory modules of signal cascades.

Three transcription-elongation factors--Spt4, Spt5, and Spt6--are conserved among eukaryotes and are essential for transcription via modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans, including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [PMID: 11182892].

GO terms

Biological Process

GO:0032784 regulation of DNA-templated transcription, elongation
GO:0006357 regulation of transcription from RNA polymerase II promoter

Molecular Function

GO:0000991 transcription factor activity, core RNA polymerase II binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PANTHER