Transcription elongation factor Spt6 (IPR017072)

Short name: TF_Spt6

Overlapping homologous superfamilies


Family relationships



Spt6 is an essential histone chaperone that mediates nucleosome reassembly during gene transcription. The N-terminal ~300 residues are highly acidic, predicted to be disordered, and are necessary for binding both nucleosomes and the transcription factor Spn1/IWS1 [PMID: 21094070]. Spt6 associates with RNAPII via a tandem Src2 homology domain [PMID: 20926373, PMID: 28826505]. Spt6-RNAPII association is required for efficient recruitment of the Ccr4-Not de-adenylation complex to transcribed genes for mRNA turnover [PMID: 29932900]. Spt6 has a key function in transcription elongation. In yeast, Spt6's interaction with phosphorylated tyrosine 1 at the C-terminal domain of RNAPII prevents pre-mature recruitment of termination factors to genes [PMID: 22745433].

GO terms

Biological Process

GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.