Transcription elongation factor Spt5, eukaryote (IPR017071)

Short name: TF_Spt5_eukaryote

Overlapping homologous superfamilies


Family relationships


This family consists of several eukaryotic transcription elongation Spt5 proteins. These proteins contain two copies of a domain (Supt5; IPR005100) that is characteristic of proteins involved in chromatin regulation. An NGN domain separates the Supt5 domains. In yeast Spt5 protein, this domain possesses a RNP-like fold and it is thought to confer affinity for Spt4 protein. Supt5 domains are followed by four to five copies of a KOW domain (IPR005824), present in many ribosomal proteins.

Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans, including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [PMID: 11182892].

This information was partially derived from InterPro (IPR009287).

GO terms

Biological Process

GO:0032784 regulation of DNA-templated transcription, elongation
GO:0006357 regulation of transcription by RNA polymerase II

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.