Protein disulphide-isomerase A4 (IPR017068)

Short name: Protein_diS-isomerase_A4

Overlapping homologous superfamilies


Family relationships


This entry represents protein disulphide-isomerase A4 (also known as endoplasmic reticulum protein 72 kDa or ERp-72) (EC:, which acts as a molecular ER chaperone. ER chaperones are critical not only for quality control of proteins processed in the ER, but also for regulation of ER signalling in response to ER stress [PMID: 17481612]. ERp-72 catalyses the rearrangement of -S-S- bonds in proteins. It is part a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. ERp-72 may functionally associate with NADPH oxidase 1 (NOX1) [PMID: 18620548].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003756 protein disulfide isomerase activity

Cellular Component

GO:0005788 endoplasmic reticulum lumen

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.