Peptidase S1A, matripase (IPR017051)

Short name: Peptidase_S1A_matripase

Overlapping homologous superfamilies


Family relationships



This group represents matriptase, which is a type II transmembrane serine peptidase belonging to MEROPS peptidase family S1A (clan PA(S)). It is involved in a number of cellular processed that include: regulation of epithelial barrier formation and permeability in the intestine [PMID: 20142489]; proteolytic cleavage of human acid-sensing ion channel 1 [PMID: 20601429] and the regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiation [PMID: 20696767].

GO terms

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.