Low density lipoprotein receptor-related protein 5/6 (IPR017049)

Short name: LRP5/6

Overlapping homologous superfamilies


Family relationships



LRP5/6 are transmembrane receptors that are involved in Wnt signal transduction [PMID: 11029007]. Binding of the Wnts to LRP5/6 and their participating co-receptors, the frizzled (Fz) family of 7 transmembrane spanning proteins, results in a series of downstream intracelullar events, in particular the inhibition by subsequent phosphorylation of GSK-3beta [PMID: 26048454]. LRP5/6 have been shown to play an role in bone homeostasis [PMID: 26048454].

Mutations in the LRP5 gene cause vitreoretinopathy, exudative 4 (EVR4), a disorder of the retinal vasculature characterised by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina [PMID: 15024691]. Mutations in the LRP6 gene cause coronary artery disease, autosomal dominant, 2 (ADCAD2), a common heart disease characterised by reduced or absent blood flow in one or more of the arteries that encircle and supply the heart [PMID: 17332414].

GO terms

Biological Process

GO:0060070 canonical Wnt signaling pathway

Molecular Function

GO:0042813 Wnt-activated receptor activity
GO:0017147 Wnt-protein binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.