Family

Virulence factor BrkB (IPR017039)

Short name: Virul_fac_BrkB

Overlapping homologous superfamilies

None.

Family relationships

Description

Members of this family include the largely uncharacterised BrkB (Bordetella resist killing by serum B) from Bordetella pertussis. It is essential for resistance to complement-dependent killing by serum in Bordetella pertussis [PMID: 7927748]. Some members have an additional C-terminal domain. Paralogs from E. coli (yhjD) and Mycobactrium tuberculosis (Rv3335c) are part of a smaller, related subfamily that form their own cluster [PMID: 1400219].

This family was originally predicted to be ribonuclease BN [PMID: 15764599] but this prediction has since been shown to be incorrect [PMID: 8955422].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
TIGRFAMs
Pfam
PIRSF