Splicing factor, SPF45 (IPR016967)

Short name: Splicing_factor_SPF45

Overlapping homologous superfamilies


Family relationships



SPF45, also termed RNA-binding motif protein 17 (RBM17), is an RNA-binding protein consisting of an unstructured N-terminal region, followed by a G-patch motif and a C-terminal U2AF (U2 auxiliary factor) homology motifs (UHM) that harbours a RNA recognition motif (RRM) and an Arg-Xaa-Phe sequence motif. SPF45 is a bifunctional protein that functions in splicing and DNA repair. It is involved in regulating alternative splicing of the apoptosis regulatory gene FAS (also called CD95). Its UHM binds UHM-ligand motifs (ULMs) present in the 3' splice site-recognizing factors U2AF65, SF1 and SF3b155 [PMID: 17589525]. It binds to the Holliday junction, which is a key DNA intermediate in the homologous-recombination pathway [PMID: 17154718, PMID: 20236180].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0043484 regulation of RNA splicing

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.