Sigma intracellular receptor 2 (IPR016964)

Short name: Sigma2_recept

Overlapping homologous superfamilies


Family relationships



Sigma-2 receptor, also known as TMEM97, is an intracellular orphan receptor highly expressed in various rapidly proliferating cancer cells and regarded as a cancer cell biomarker. It is a cytochrome-related protein that binds to various pharmacological compounds, and modulates the cytosolic Ca2+ concentration, dopaminergic transmission, and cocaine-induced addiction behavior [PMID: 23922215, PMID: 22292588, PMID: 25620095]. It may have a role as regulator of cellular cholesterol homeostasis [PMID: 19583955] and function as a sterol isomerase [PMID: 25566323].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.