Anaphase-promoting complex subunit APC10/Doc1 (IPR016901)

Short name: APC10/Doc1

Overlapping homologous superfamilies

Family relationships



The anaphase-promoting complex (APC) or cyclosome is a multi-subunit E3 protein ubiquitin ligase that regulates important events in mitosis, such as the initiation of anaphase and exit from telophase. The APC, in conjunction with other enzymes, assembles multi-ubiquitin chains on a variety of regulatory proteins, thereby targeting them for proteolysis by the 26S proteasome.

One of the subunits of the APC that is required for its ubiquitination activity is Doc1/Apc10, a protein composed of a Doc1 homology domain that has been identified in a number of diverse putative E3 ubiquitin ligases [PMID: 11884135]. The Doc1 homology domain forms a beta-sandwich structure that is related in architecture to the galactose-binding domain of galactose oxidase, the coagulation factor C2 domain and a domain of XRCC1. This group represents a subgroup of subunit 10.

GO terms

Biological Process

GO:0031145 anaphase-promoting complex-dependent catabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005680 anaphase-promoting complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.