Family

Alpha-2-glucosyltransferase Alg10 (IPR016900)

Short name: Alg10

Family relationships

None.

Description

Alg10 (asparagine-linked glycosylation) (EC:2.4.1.256) is a dolichyl-phosphoglucose-dependent glucosyltransferase which adds the terminal alpha-1,2 glucose to the lipid-linked Glc2Man9GlcNAc2 oligosaccharide. The terminal alpha-1,2-linked glucose residue is important for substrate recognition by the oligosaccharyltransferase [PMID: 9597543]. In Saccharomyces cerevisiae, Alg10 has a role in regulation of the expression of a myo-inositol transporter, Itr1 (hence the name Die2, standing for derepression of Itr1 expression) [PMID: 7565092]. It also regulates the expression of Ino1, which is an inositol-3-phosphate synthase [PMID: 7565092]. Alg10 is homologous to human and rat potassium channel regulatory protein KCR1, which diminishes the cardiac repolarising current I(Kr) drug response [PMID: 17189275, PMID: 9722534].

GO terms

Biological Process

GO:0006488 dolichol-linked oligosaccharide biosynthetic process

Molecular Function

GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity

Cellular Component

GO:0005789 endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
Pfam
PANTHER