Mitochondrial transcription factor TFB2 (IPR016861)

Short name: TFB2M

Overlapping homologous superfamilies

Family relationships


rRNA methyltransferase-related mitochondrial transcription factors B1 (TFB1M) and B2 (TFB2M) perform unique, yet cooperative functions. In addition to being mitochondrial transcription factors, they can dimethylate two adjacent adenines in a stem-loop structure close to the 3' end of the small subunit rRNA, a modification that is highly conserved in nature [PMID: 16533820, PMID: 16533820]. The primary function of TFB2 is mtDNA transcription and maintenance, which is independent of its rRNA methyltransferase activity, while that of TFB1M is mitochondrial rRNA methylation [PMID: 19417006]. TFB1M and TFB2M.

This family represents TFB2M. Compared to TFB1M, TFB2M activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity [PMID: 12068295].

GO terms

Biological Process

GO:0031167 rRNA methylation
GO:0006355 regulation of transcription, DNA-templated
GO:0006391 transcription initiation from mitochondrial promoter

Molecular Function

GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity
GO:0003712 transcription cofactor activity

Cellular Component

GO:0005739 mitochondrion

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.