Ribonuclease P/MRP, p29 subunit (IPR016848)

Short name: RNase_P/MRP_p29-subunit

Overlapping homologous superfamilies


Family relationships



This entry represents the p29 subunit (also known as Rpp29 or Pop4) of the related ribonucleoproteins ribonuclease (RNase) P and RNase MRP from eukaryotes [PMID: 10352175]. Rpp29 has a conserved C-terminal domain with an Sm-like fold [PMID: 15518563]. Rpp29 (EC: catalyses the endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. It interacts with the Rpp25 and Pop5 subunits.

RNase P is a protein complex that generates mature tRNA molecules by cleaving their 5'-ends [PMID: 14550630]. RNase P consists of an RNA moiety and multiple protein subunits. In Saccharomyces cerevisiae (Baker's yeast), RNase P consists of 9 protein subunits (Pop1, Pop3-8, Rpr2 and Rpp1), while in humans there are 10 subunits (Rpp14, 20, 21, 25, 29, 30, 38, 40, hPop1, 5). Rpp29 may function with Rpp38 to coordinate the nucleolar targeting and/or assembly of RNase P. Rpp29 interacts with the catalytic M1 RNA subunit of RNase P and precursor tRNA and can activate M1 RNA.

RNase MRP (mitochondrial RNA processing) is an rRNA processing enzyme that cleaves a specific site within precursor rRNA to generate the mature 5'-end of 5.8S rRNA [PMID: 15916546]. RNase MRP also cleaves primers for mitochondrial DNA replication and CLB2 mRNA. In yeast, RNase MRP possesses one putatively catalytic RNA and at least 9 protein subunits and is highly related to RNase P (Pop1, Pop3-Pop8, Rpp1, Snm1 and Rmp1).

GO terms

Biological Process

GO:0006379 mRNA cleavage
GO:0006364 rRNA processing
GO:0008033 tRNA processing

Molecular Function

GO:0003723 RNA binding
GO:0004540 ribonuclease activity

Cellular Component

GO:0005655 nucleolar ribonuclease P complex
GO:0000172 ribonuclease MRP complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.