Transcriptional adaptor 2 (IPR016827)
Short name: Ada2/TADA2
Overlapping homologous superfamilies
- Transcriptional adaptor 2 (IPR016827)
- Transcriptional adapter ADA2, plants (IPR034318)
This entry represents a group of transcriptional adaptors, including transcriptional adapter 2 (TADA2) from animals and plants, and Ada2 from yeasts.
There are two Drosophila Ada2 homologues, dAda2a and dAda2b. dAda2b is a component of Spt-Ada-Gcn5-acetyltransferase (SAGA) complexes, while dAda2a associates with dGcn5 but is not incorporated into dSAGA-type complexes [PMID: 12697829].
Mammalian TADA2 is a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. The ATAC complex is involved in mammalian development, histone acetylation, cell cycle progression, and prevention of apoptosis during embryogenesis [PMID: 19103755].
- PIRSF025024 (Transcriptional_adaptor_2)