Vesicle-associated membrane-protein-associated protein (IPR016763)

Short name: VAP

Overlapping homologous superfamilies


Family relationships


This entry represents a family of vesicle-associated membrane-protein-associated proteins (VAPs) and plant VAP homologs (PVAPs) [PMID: 19207211]. VAPs (VAPA and VAPB in humans, VAPA, VAPB and VAPC in other mammals [PMID: 9920726]) are endoplasmic reticulum (ER) proteins that play roles in vesicle trafficking, neurotransmitter release, microtubule organisation, lipid transport and unfolded protein response [PMID: 18468439]. VAP proteins contain an MSP domain in their N-terminal half, which has been shown to interact with proteins containing a FFAT motif, such as members of the oxysterol-binding protein (OSBP) family or the phosphatidylinositol transfer proteins from the PITPNM family [PMID: 18468439]. Yeast VAP homologues are known as Scs2 and Scs22 [PMID: 15668246].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005789 endoplasmic reticulum membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.