Nuclear factor interleukin-3-regulated protein (IPR016743)

Short name: NFIL3/E4BP4

Overlapping homologous superfamilies


Family relationships



Nuclear factor interleukin-3-regulated protein (NFIL3, also known as E4BP4) was first identified as a transcriptional repressor capable of binding an activating transcription factor (ATF) DNA consensus sequence site in the adenovirus E4 promoter [PMID: 1620116]. Later, it was independently identified as a transactivator of the IL3 promoter in human T cells [PMID: 7565758].

E4BP4 is involved in a several biological processes, including transcriptional control of the circadian clock, neuron growth and survival, osteoblast function, and regulation of ovulation [PMID: 22075207]. It is essential for the development of NK cells and CD8alpha(+) conventional dendritic cells, and is also involved in macrophage activation, polarisation of CD4(+) T cell responses and B cell class switching to IgE [PMID: 22075207].

GO terms

Biological Process

GO:0006955 immune response
GO:0006366 transcription by RNA polymerase II

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.