FADD (IPR016729)

Short name: FADD

Overlapping homologous superfamilies

Family relationships



This entry represents the Fas-associated death domain protein FADD. This is an apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate, called the death-inducing signalling complex (DISC), performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. For further information see [PMID: 7538907, PMID: 9582077, PMID: 11034606, PMID: 12702765, PMID: 16127453].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.