Calcium signal-modulating cyclophilin ligand (IPR016719)

Short name: Ca_signal-mod_cyclophilin_lig

Overlapping homologous superfamilies


Family relationships



This group represents a calcium signal-modulating cyclophilin ligand (CAML). Immunophilins consist of a family of highly conserved proteins binding with immunosuppressive drugs such as FK506, rapamycin and cyclosporin A [PMID: 18635947]. The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin, cyclosporin A binds and inactivates the key signalling intermediate calcineurin. CAML acts downstream of the TCR and upstream of calcineurin by causing an influx of calcium [PMID: 7522304].

The HIV-1 Vpu protein is required for efficient viral release from human cells. CAML is a Vpu-interacting host factor that restricts HIV-1 release. CAML is probably the mechanistic link between the two viral regulators Vpu and HIV-2 Env [PMID: 18500349].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.