Family

Aspartoacylase (IPR016708)

Short name: Aspartoacylase

Family relationships

Description

Aspartoacylase (ASPA) is the N-acetylaspartate- (NAA)-hydrolysing enzyme. It catalyses the deacetylation of N-acetyl-L-aspartate to produce L-aspartate and acetate. N-phosphonomethyl-L-aspartate is a potent inhibitor of this enzyme [PMID: 18293939]. There is a high concentration of (NAA) in neurons of the central nervous system, which is used as an indicator of neuronal viability. The myelin-associated pathology; Canavan disease (also known as spongy degeneration of the brain), is an inherited childhood disorder that results from a mutation of ASPA. The dysmyelination that results from the inactivation of ASPA is characterised by selective decreases as well as some increases in specific lipids [PMID: 18478328].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
HAMAP
PIRSF