Aspartoacylase (IPR016708)

Short name: Aspartoacylase

Overlapping homologous superfamilies


Family relationships


Aspartoacylase (ASPA) is the N-acetylaspartate- (NAA)-hydrolysing enzyme. It catalyses the deacetylation of N-acetyl-L-aspartate to produce L-aspartate and acetate. N-phosphonomethyl-L-aspartate is a potent inhibitor of this enzyme [PMID: 18293939]. There is a high concentration of (NAA) in neurons of the central nervous system, which is used as an indicator of neuronal viability. The myelin-associated pathology; Canavan disease (also known as spongy degeneration of the brain), is an inherited childhood disorder that results from a mutation of ASPA. The dysmyelination that results from the inactivation of ASPA is characterised by selective decreases as well as some increases in specific lipids [PMID: 18478328].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.