Family

3-hydroxyanthranilate 3, 4-dioxygenase, metazoan (IPR016700)

Short name: 3hydroanth_dOase_met

Family relationships

Description

This group represents a 3-hydroxyanthranilate 3,4-dioxygenase found in metazoan species, especially animals. 3-Hydroxyanthranilic acid 3,4-dioxygenase (3HAO) is a non-heme ferrous extradiol dioxygenase in the kynurenine pathway from tryptophan. It catalyzes the conversion of 3-hydroxyanthranilate (HAA) to quinolinic acid (QUIN), an endogenous neurotoxin, via the activation of N-methyl-D-aspartate (NMDA) receptors and the precursor of NAD+ biosynthesis [PMID: 16522801]. Kynurenine pathway metabolism has been implicated in neurological disease [PMID: 1422788].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0046872 metal ion binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF