Acid ceramidase-like (IPR016699)

Short name: Acid_ceramidase-like

Overlapping homologous superfamilies


Family relationships



This group represents acid ceramidases and some related proteins of currently unknown function. Ceramide is hydrolyzed by both acid and alkaline ceramidase [PMID: 8203897]. Acid ceramidase requires saposin D, a sphingolipid activator protein, for the lysosomal breakdown of ceramide to a fatty acid and sphingosine [PMID: 18453694]. Ceramide is found in plasma membranes and plays a pivotal role in the metabolism of sphingolipids. In addition, ceramide and sphingosine may have important roles as second messengers for cell function and survival [PMID: 8203897].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005764 lysosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.