Family

Acid ceramidase-like (IPR016699)

Short name: Acid_ceramidase-like

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This group represents acid ceramidases and some related proteins of currently unknown function. Ceramide is hydrolyzed by both acid and alkaline ceramidase [PMID: 8203897]. Acid ceramidase requires saposin D, a sphingolipid activator protein, for the lysosomal breakdown of ceramide to a fatty acid and sphingosine [PMID: 18453694]. Ceramide is found in plasma membranes and plays a pivotal role in the metabolism of sphingolipids. In addition, ceramide and sphingosine may have important roles as second messengers for cell function and survival [PMID: 8203897].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005764 lysosome

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF