Sulfiredoxin (IPR016692)

Short name: Sulfiredoxin

Overlapping homologous superfamilies

Family relationships



Sulfiredoxins EC: belong to the oxidoreductase family, which are involved in cellular responses to oxidative stress [PMID: 16102934]. They catalyse the reaction peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R

It is a member of a conserved family of eukaryotic antioxidants and contains a conserved C-terminal cysteine which is essential for its antioxidant function.

Sulfiredoxin (Srx) plays a role in signalling through the catalytic reduction of oxidative modifications. It is responsible for the regulation of peroxiredoxin (Prx) by catalysing reduction of the conserved cysteine from sulfinic to sulfenic acid. This reduction prevents further reduction to sulfonic acid, which ultimately results in degradation.

Srx also has a role in glutathionylation.

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0032542 sulfiredoxin activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.