Family

ESCRT-2 complex, Snf8 (IPR016689)

Short name: ESCRT-2_cplx_Snf8

Overlapping homologous superfamilies

Family relationships

None.

Description

Snf8 (also known as Vps22p/Eap30) is a subunit of ESCRT-II, a protein complex involved in driving protein sorting from endosomes to lysosomes.

The multivesicular body (MVB) protein-sorting pathway targets transmembrane proteins either for degradation or for function in the vacuole/lysosomes. The signal for entry into this pathway is monoubiquitination of protein cargo, which results in incorporation of cargo into luminal vesicles at late endosomes. Another crucial player is phosphatidylinositol 3-phosphate (PtdINS(3)P), which is enriched on early endosomes and on the luminal vesicles of MVBs. ESCRT (endosomal sorting complex required for transport)-I, -II and -III complexes are critical for MVB budding and sorting of monoubiquitinated cargo into the luminal vesicles [PMID: 17450176].

GO terms

Biological Process

GO:0071985 multivesicular body sorting pathway

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0000814 ESCRT II complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
PANTHER