RNA-induced silencing complex, nuclease component Tudor-SN (IPR016685)

Short name: Silence_cplx_Nase-comp_TudorSN

Overlapping homologous superfamilies


Family relationships



This entry represents the Tudor staphylococcal nuclease (Tudor-SN) subunit of the RNA-induced silencing complex (RISC) [PMID: 15895094, PMID: 17715366]. RISC is central to the mechanism of RNA interference (RNAi), which is triggered by the presence of dsRNA, resulting in silencing of the cognate gene. In RNAi, dsRNA is processed by RNase III ribonucleases (from Dicer family) to yield small interfering RNAs (siRNAs), which are unwound and incorporated into the RISC ribonucleoprotein complex that ultimately targets the cognate mRNA. Various components of the RISC have been identified that are highly conserved between species. In Drosophila melanogaster (Fruit fly) these subunits include the proteins Argonaute2, VIG, FXR and Tudor-SN. Tudor-SN binds to hyper-edited double-stranded RNA and promotes its cleavage.

GO terms

Biological Process

GO:0031047 gene silencing by RNA

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016442 RISC complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.