Ubiquitinyl hydrolase (IPR016652)

Short name: Ubiquitinyl_hydrolase

Overlapping homologous superfamilies

Family relationships



This entry includes a group of ubiquitinyl hydrolases, also known as ubiquitin carboxyl-terminal hydrolases, including USP13 and USP5 from animals, and Ubp14 from plants and fungi.

Budding yeast Ubp14 may facilitate proteolysis by preventing unanchored ubiquitin chains from competitively inhibiting polyubiquitin-substrate binding to the 26S proteasome [PMID: 12686616, PMID: 9305625].

USP5 recognizes and recycles the unanchored polyUb chain to keep the free Ub pool stable [PMID: 19098288]. USP13 is an ortholog of USP5. However, unlike USP5, USP13 exhibits a weak deubiquitinating activity preferring to Lys63-linked polyubiquitin (K63-polyUb) in a non-activation manner. It may function differently from USP5 in cellular deubiquitination processes [PMID: 22216260].

GO terms

Biological Process

GO:0016579 protein deubiquitination

Molecular Function

GO:0004843 thiol-dependent ubiquitin-specific protease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.