Leucine carboxyl methyltransferase 1, LCMT1 (IPR016651)

Short name: Leu_CO_MeTrfase_LCMT1

Overlapping homologous superfamilies

Family relationships


Leucine carboxymethyltransferases methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. It includes LCTM1 which regulate the activity of serine/threonine phosphatase 2A (PP2A) through methylation of the C-terminal leucine residue of the catalytic subunit of PP2A [PMID: 10600115, PMID: 11697862, PMID: 11060018]. This affects the heteromultimeric composition of PP2A which in turn affects protein recognition and substrate specificity. Like many other methyltransferases LCTM1 uses S-adenosylmethionine (SAM) as the methyl donor. LCTM1 contains the common SAM-dependent methyltransferase core fold, with various insertions and additions creating a specific PP2A binding site [PMID: 14660564].

This group represents the LCMT1 subgroup of leucine carboxymethyltransferases.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008168 methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.