Family

PR domain zinc finger protein 1 (IPR016608)

Short name: PRDM1

Family relationships

None.

Description

PR domain zinc finger protein 1 (PRDM1, also known as BLIMP-1) is a transcriptional repressor that is essential for cellular development. This entry includes BLIMP-1 from vertebrates and its homologues from invertebrates.

In vertebrates, PRDM1 is also known as B lymphocyte-induced maturation protein 1 (BLIMP-1) or positive regulatory domain I-binding factor (PRDI-BF1). It is essential for the differentiation of B and T cells [PMID: 25015830].

In Caenorhabditis elegans, it regulates the spatiotemporal cell migration pattern [PMID: 24968003]. The degradation of PRDM1 by DRE-1/FBXO11-dependent mechanism regulates the C. elegans developmental timing and maturation [PMID: 24613396].

GO terms

Biological Process

GO:0048869 cellular developmental process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter

Molecular Function

GO:0003700 transcription factor activity, sequence-specific DNA binding

Cellular Component

GO:0005737 cytoplasm
GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF