Family

Suppressor of fused, eukaryotic (IPR016591)

Short name: Suppressor_of_fused_euk

Family relationships

Description

Sufu, encoding the human ortholog of Drosophila suppressor of fused, appears to have a conserved role in the repression of Hedgehog signalling. It is a repressor of the Gli and Ci transcription factors of the Hedgehog signalling cascade [PMID: 12150819], and functions by binding these proteins and preventing their translocation to the nucleus. Sufu has been found to be a tumour-suppressor gene that predisposes individuals to medulloblastoma by modulating the SHH signalling pathway [PMID: 12068298]. Homologues of Sufu have been found in bacteria, though their function is not currently known.

This entry is specific for the eukaryotic Sufu proteins and does not include any homolgous bacterial sequences.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008134 transcription factor binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF