Pathways & interactions
DNA damage checkpoint control protein Rad17 (IPR016587)
Short name: Rad17
Overlapping homologous superfamilies
- Rad1/Rec1/Rad17 (IPR003021)
- DNA damage checkpoint control protein Rad17 (IPR016587)
This entry represents Rad17 from budding yeast (the homologue of human and S. pombe Rad1). Rad17 is a component of the checkpoint clamp complex (Ddc1/Mec3/Rad17) involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes [PMID: 8649984, PMID: 7491494, PMID: 9891048]. In S. cerevisiae, the Ddc1-Mec3-Rad17 complex associates with sites of DNA damage and modulates the Mec1 signaling pathway and the activation of Rad53 in response to DNA damage at phase G1 [PMID: 9670034]. The complex also physically regulates DNA polymerase zeta-dependent mutagenesis by controlling the access of polymerase zeta to damaged DNA [PMID: 16169844]. Contrary to its human counterpart, the 9-1-1 complex, the checkpoint clamp complex shows no detectable exonuclease activity [PMID: 12604797].
It's worth noting that the name, Rad17, has been used for a different protein in human and S. pombe. The homologue of the human and S. pombe Rad17 in budding yeast is Rad24.
- PIRSF011769 (Cell_cycle_RAD17)