Cell cycle checkpoint, Hus1 (IPR016580)

Short name: Cell_cycle_HUS1

Overlapping homologous superfamilies


Family relationships


Hus1 is a component of the 9-1-1 cell-cycle checkpoint response complex (which consists of Rad9, Hus1, Rad1), a key complex in the coordination of DNA damage sensing, cell cycle progression and DNA repair pathways. In humans, the 9-1-1 complex is recruited to DNA lesions upon damage by the RAD17-replication factor C (RFC) clamp loader complex. It activates checkpoint response and acts as a sliding clamp platform on DNA for several proteins involved in DNA repair. The 9-1-1 complex is necessary for the recruitment of C12orf32/RHINO to sites of double-stranded breaks (DSB) occurring during the S phase [PMID: 21659603].

GO terms

Biological Process

GO:0000077 DNA damage checkpoint

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030896 checkpoint clamp complex
GO:0005730 nucleolus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.