Adenylate cyclase, type 10 (IPR016577)

Short name: Adenylate_cyclase_typ10

Overlapping homologous superfamilies


Family relationships



This entry represents type 10 adenylate cyclases (also known as soluble adenylyl cyclase; EC:, which produces cAMP and phosphate from ATP. This enzyme has a critical role in mammalian spermatogenesis by producing cAMP to mediate the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis [PMID: 18255013]. This induces capacitation, the maturational process that sperm undergo prior to fertilization. Soluble adenylyl cyclase binds 2 magnesium ions per subunit, and is activated by manganese or magnesium ions. The enzyme is activated by bicarbonate in the presence of magnesium ions, and inhibited by bicarbonate i nthe presence of manganese ions. Genetic variations in the gene that encodes this enzyme (ADCY10) are associated with absorptive hypercalciuria type 2 (HCA2) (OMIM:143870).

GO terms

Biological Process

GO:0006171 cAMP biosynthetic process
GO:0007283 spermatogenesis

Molecular Function

GO:0004016 adenylate cyclase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.