Phospholipase D, eukaryotic type (IPR016555)

Short name: PLipase_D_euk

Overlapping homologous superfamilies


Family relationships


This entry includes the lipid-signaling enzymes phospholipase D1 (PLD1) and D2 (PLD2) [PMID: 9395408]. They have roles in immune cell migration [PMID: 20647543, PMID: 19325080] and phagocytosis [PMID: 15294978, PMID: 16497229]. PLD1 is selectively required during extravasation of macrophages from the bloodstream to sites of damage [PMID: 23383154].

GO terms

Biological Process

GO:0048017 inositol lipid-mediated signaling
GO:0006654 phosphatidic acid biosynthetic process

Molecular Function

GO:0004630 phospholipase D activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.