Family

Vacuolar protein sorting-associated protein 11 (IPR016528)

Short name: VPS11

Overlapping homologous superfamilies

None.

Family relationships

None.

Description

This entry includes E3 ubiquitin-protein ligase Pep5 (also known as vacuolar protein sorting-associated protein 11, Vps11) from fungi, and its homologues from plants and animals. Pep5 is a peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis [PMID: 10978279]. It is also identified as an E3 ubiquitin ligase that regulates histone protein levels in Saccharomyces cerevisiae [PMID: 22570702]. Human Vps11 may play a role in vesicle-mediated protein trafficking [PMID: 11382755].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
PIRSF