5'-3' exoribonuclease 1 (IPR016494)

Short name: 5_3_exoribonuclease_1

Overlapping homologous superfamilies


Family relationships


5'-3'-exoribonucleases are enzymes that degrade RNA by removing terminal nucleotides from the 5' end. 5'-3'exoribonuclease type 1 (Xrn1, also known as kem1) occurs in animal and fungal lineages. In Saccharomyces cerevisiae, Xrn1 can be activated by Dcs1, a non-essential hydrolase that involved in mRNA decapping. The activation of Xrn1 by Dcs1 is important for respiration [PMID: 22570495].

GO terms

Biological Process

GO:0000956 nuclear-transcribed mRNA catabolic process

Molecular Function

GO:0008409 5'-3' exonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.