Transcription elongation factor, TFIIS-related (IPR016492)

Short name: TF_IIS-rel

Family relationships


This entry represents transcription elongation factors of the IIS type. It also includes TFIIS-related proteins. TFIIS is a component of RNA polymerase II preinitiation complexes, and is required for preinitiation complex assembly and stability [PMID: 17913884]. The association of TFIIS with a promoter depends on functional preinitiation complex components including Mediator and the SAGA complex [PMID: 17901206]. TFIIS is composed of three domains: domain 1 forms a 4-helical bundle that appears to bind certain initiation factors; domain 2 forms a 3-helical bundle and is required for Pol II binding; domain 3 forms a zinc ribbon and is essential for stimulation of RNA cleavage [PMID: 16648364, PMID: 10940308].

GO terms

Biological Process

GO:0032784 regulation of DNA-templated transcription, elongation
GO:0006357 regulation of transcription from RNA polymerase II promoter

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.