Family

Carbohydrate sulfotransferase (IPR016469)

Short name: Carbohydrate_sulfotransferase

Family relationships

None.

Description

This entry represents carbohydrate sulphotransferase, which catalyses the transfer of a sulphate to position 6 of the galactose (Gal) residues in keratan. It may function in the sulphation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins and participate in the biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Carbohydrate sulphotransferase CHST1, CHST2, CHST3, and CHST4 are all involved in producing functional L-selectin ligands [PMID: 11310842].

Deficiency of CHST3 (also known as chondroitin-6-sulphotransferase) has been associated with severe chondrodysplasia with progressive spinal involvement [PMID: 18513679]. Macular corneal dystrophy (MCD) has also been shown to be caused by mutations in the carbohydrate sulphotransferase 6 gene (CHST6) [PMID: 11139648].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0008146 sulfotransferase activity

Cellular Component

GO:0000139 Golgi membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF