Flavin oxidoreductase Frp family (IPR016446)

Short name: Flavin_OxRdtase_Frp

Overlapping homologous superfamilies

Family relationships



Reduced flavins participate in numerous biochemical processes. NAD(P)H-flavin oxiodoreductases (flavin reductases) catalyses the reduction of flavin by NAD(P)H. The representative member of this family, Frp (flavin reductase P), is a supplier of reduced flavin mononucleotide (FMNH2) to the bioluminescence reaction in Vibrio harveyi [PMID: 8206832, PMID: 8885832, PMID: 22650604].

Oxygen-insensitive NADPH nitroreductase also belongs to this family. It catalyses the reduction of nitroaromatic compounds using NADH. It is a major component of the oxygen-insensitive nitroreductase activity of some bacteria, such as E.coli [PMID: 8755878].

Both the reductase and nitroreductase are homodimeric flavoproteins that contain one FMN per monomer as a cofactor [PMID: 11034992].

GO terms

Biological Process

GO:0055114 oxidation-reduction process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.