RNA 3'-terminal phosphate cyclase type 2 (IPR016443)

Short name: RNA3'_term_phos_cyc_type_2

Overlapping homologous superfamilies

Family relationships


RNA cyclases are a family of RNA-modifying enzymes that are conserved in eukaryotes, bacteria and archaea. Type 1 RNA 3'-terminal phosphate cyclases (EC: [PMID: 9184239, PMID: 2199762] catalyse the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA:

ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate

The physiological function of the cyclase is not known, but the enzyme could be involved in the maintenance of cyclic ends in tRNA splicing intermediates or in the cyclisation of the 3' end of U6 snRNA [PMID: 9184239].

A second subfamily of RNA 3'-terminal phosphate cyclases (type 2) that do not have cyclase activity have been identified in eukaryotes. They are localised to the nucleolus and are involved in ribosomal modification [PMID: 10790377].

This entry represents the type 2 RNA 3'-terminal phosphate cyclases, also known as RNA'-terminal-phosphate-cyclase-like (Rcl) proteins [PMID: 10790377].

GO terms

Biological Process

GO:0042254 ribosome biogenesis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005730 nucleolus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.