Sphingosine N-acyltransferase Lag1/Lac1-like (IPR016439)

Short name: Lag1/Lac1-like

Overlapping homologous superfamilies


Family relationships



Yeast ceramide synthase component Lag1 has a a paralog, Lac1. This entry includes Lac1, Lag1 and their homologues from plants and animals [PMID: 12445127, PMID: 12105227]. They may be involved in sphingolipid synthesis.

LAG1 and LAC1 contain multiple membrane-spanning domains and are localised to the endoplasmic reticulum (ER) [PMID: 10198056]. They are essential subunits of the acyl-CoA-dependent ceramide synthase that is involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine [PMID: 15692566, PMID: 15236759, PMID: 11694577].

Human Lac1/Lag1 homologue CERS2 (ceramide synthase 2) is a tumour metastasis suppressor that can inhibit breast cancer cell invasion [PMID: 25213553].

Tomato Lac1/Lag1 homologue ASC1 can mediate resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis [PMID: 12445127].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.