Family

Diphthamide synthesis DPH1/DPH2 (IPR016435)

Short name: DPH1/DPH2

Family relationships

Description

Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called diphthamide, the target of the diphtheria toxin. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide in EF2 [PMID: 15485916].

Members of this family include DPH1 and DPH2, which are involved in the first step of diphthamide synthesis [PMID: 15485916]. Archaeal DPHs are more similar to eukaryotic DPH1 than to DPH2 [PMID: 20559380].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs
Pfam
PANTHER