Spanin, inner membrane subunit, T7likevirus-type (IPR016417)

Short name: i-spanin_T7likevirus

Family relationships


The lysis of Gram-negative hosts by double-strand DNA bacteriophages requires, in addition to the actions of a holin and endolysin, a third step involving the spanin complex. This complex consists of a small outer membrane lipoprotein and an integral cytoplasmic membrane protein, designated as o-spanins and i-spanins, respectively. The spanin complex is involved in the disruption of the outer membrane. Without spanin function, lysis is blocked and progeny virions are trapped in dead spherical cells [PMID: 24585055].

This entry represents the i-spanin subunit, mainly from T7-like viruses.

GO terms

Biological Process

GO:0019076 viral release from host cell

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
  • PD033200 (Phge_lysis-endo-Pept_T7/18-5)