Histone acetyltransferase GCN5/PCAF (IPR016376)

Short name: GCN5/PCAF

Overlapping homologous superfamilies


Family relationships


Eukaryotic GCN5 acetyltransferases influence diverse biological processes by acetylating histones and non-histone proteins and regulating chromatin and gene-specific transcription as part of multiprotein complexes. Vertebrate organisms, express two paralogous GCN5-like acetyltransferases, GCN5 and PCAF (also known as KAT2A and KAT2B), which is included in this entry [PMID: 18838386]. GCN5/PCAF is a component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 [PMID: 19103755, PMID: 8684459].

GO terms

Biological Process

GO:0016573 histone acetylation
GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0004402 histone acetyltransferase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.