Family

Transcription factor GATA-4/5/6 (IPR016375)

Short name: TF_GATA_4/5/6

Family relationships

Description

This entry represents the GATA family of transcription factors, such as GATA-4, GATA-5 and GATA-6. These transcription factors regulate critical steps of cellular differentiation during vertebrate development. GATA-4, 5 and 6 each contain two GATA-type zinc fingers, and are known to activate numerous enterocytic genes [PMID: 16603485, PMID: 14715527]. Loss of GATA-4 and GATA-5 has been reported in human gastric and colon cancer [PMID: 16823849].

GATA-4 binds to the consensus sequence 5'-AGATAG-3', and acts as a transcriptional activator of Anf in cooperation with Nkx2-5 [PMID: 2941624]. It interacts with the homeobox domain of Nkx2-5 through its C-terminal zinc finger. It also interacts with Jarid2 which represses its ability to activate transcription of Anf. Defects in GATA-4 are the cause of atrial septal defect type 2 (ASD2) (OMIM:607941)[PMID: 10948187]. ASD2 is a congenital heart malformation characterised by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.

GATA-5 binds to the functionally important Cef-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer [PMID: 9119112]. It may play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF